The Indian government refused to stop HCQ and is even expanding it to prophylaxis for government officials and anybody who could be touch with coronavirus. However, the explanation is very interesting:Not so good news on the HCQ/CQ front. A large retrospective study by the Lancet covering over 90k patients over 600+ hospitals showed that those treated with HCQ/CQ had higher death rates than standard of care, and those treated with HCQ/CQ + macrolide (azithromycin) had an even higher death rate.
Based on this study the WHO has recommended stopping treatment using HCQ/CQ. Indonesia has stopped its use on its WHO solidarity trail study, but is still using them for other patients.
Organisasi Kesehatan Dunia (WHO) meminta penggunaan klorokuin pada pasien Corona disetop. Pakar dari gugus tugas menyebut Indonesia sudah mematuhinya.health.detik.com
The study, while appearing robust, has drawn criticism from other scientists, particularly over the origin of the data used.
Exclusive: Australian researchers query origin of data used for Lancet study, but stress there is no evidence drug is a safe or effective treatmentwww.theguardian.com
This really leaves me wondering why a proper double-blinded study is not being done by anyone? It seems both proponents and detractors of using HCQ/CQ to treat Covid-19 are more interested in advancing their theories rather than actually doing a proper study.
"Currently, as per protocols set by the Indian government to treat severe coronavirus patients requiring ICU management, HCQ dosages are administered in the following way- 1st day a heavy dose of 400mg HCQ dose once in the morning and one at night, followed by 200 mg HCQ one in the morning and one at night to be followed for the next four days. The total dosage administered to a patient in 5 days, therefore, amounts to 2400 mg. "
and underlying the WHO Solidarity trial:
"...Internationally in Solidarity trial COVID-19 patients are being administered with--800 mg x 2 loading doses 6 hours apart followed by 400 mg x 2 doses per day for 10 days. The total dosage given to a patient over 11 days is about 9600 mg which is four times higher than the dose we are giving to our patients," informed the official.
This indicates that in our treatment protocol, the efficacy of HCQ is good and patients are recovering quickly with less amount of dosage being administered," said the official."
Just to mention that overdose of HQC starts at 1000-2000 mg.
As per the producer's specifications, maximum loading dosage is 800 mg followed by 400mg 6 hours apart, and regular usage should not exceed daily 400mg/600mg in some cases.